Research

In the News

A review of DNA repair and possible DNA-repair adjuvants and selected natural anti-oxidants

Emanuel, P., Scheinfeld, N.
Dermatology Online Journal
Reprinted with the permission of Dr. Noah Scheinfeld, M.D., J.D.

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Botanical extract protects against UV

Jesitus, J.
Dermatology Times - Modern Medicine
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C-MED-100: a novel, natural compound that averts inflammation and protects natural immunity through DNA repair

Meiss, D., Ralston J.S.
Nutraceutical News

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DNA repair: Its importance and how to improve it—An interview with Dr. Noah Scheinfeld

Passwater, R.A.
Whole Foods Magazine

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DNA Repair: Maintaining performance and appearance at any age

Editorial
Inside Fitness Magazine

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The role of AC-11, liposome lotion, dimericine and selenium in enhancing health and preventing skin cancer

Scheinfeld, N.
DNA Repair Adjuvants
Reprinted with the permission of Dr. Noah Scheinfeld, M.D., J.D.

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Links
Journal Articles

An active ingredient of cat's claw water extracts: Identification and efficacy of quinic acid

Sheng, Y., Åkesson, C., Holmgren, K., Bryngelsson, C., Giamapa, V
Journal of Ethnopharmacology

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An extract of Uncaria tomentosa inhibiting cell division and NF-κB activity without inducing cell death

Åkesson, C., Lindgren, H., Pero, R.W., Leanderson, T., Ivars, F.
International Immunopharmacology

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Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae)

Aguilar, J.L., Rojas, P., Marcelo, A., Plaza, A., Bauer, R., Reininger, E., Klaas, C.A., Merfort, I.
Journal of Ethnopharmacology

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A water soluble extract from Uncaria tomentosa (cat’s claw) is a potent enhancer of DNA repair in primary organ cultures of human skin

Mammone, T., Åkesson, C., Gan, D., Vojdani, A.
Phytotherapy Research

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Comparison of a broad spectrum anti-aging nutritional supplement with and without the addition of a DNA repair enhancing cat’s claw extract

Pero, R.W., Giampapa, V., Vodjani, A.
Journal of Anti-Aging Medicine

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C-MED-100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo

Åkesson, C., Pero, R.W., Ivars, F.
Phytomedicine

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Journal Articles

DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study

Sheng, Y., Li, L., Holmgren, K., Pero, R.W.
Phytomedicine

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Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa

Sheng, Y., Bryngelsson, C., Pero, R.W.
Journal of Ethnopharmacology

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Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa

Sheng, Y., Pero, R.W., Amiri, A., Bryngelsson, C.
Anticancer Research

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Persistent response to pneumococcal vaccine in individuals supplemented with a novel water-soluble extract of Uncaria tomentosa, C-MED-100

Lamm, S., Sheng, Y., Pero, R. W.
Phytomedicine

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Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100

Åkesson, C., Lindgren, H., Pero, R.W., Leanderson, T., Ivars, F.
International Immunopharmacology

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Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from

Sheng, Y., Pero, R.W., Wagner, H.
Phytomedicine

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Related Articles

Antioxidant metabolism induced by quinic acid: Increased urinary excretion of tryptophan and nicotinamide

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DNA repair enhancement by a combined supplement of carotenoids, nicotinamide, and zinc

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Related Articles

Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements

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Health consequences of catabolic synthesis of hippuric acid in humans

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In vivo treatment of humans with quinic acid enhances DNA repair and reduces the influence of lifestyle factors on risk to disease

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Low serum thiol levels predict shorter times-to-death among HIV-infected injecting drug users

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Markers of DNA repair and susceptibility to cancer in humans: An epidemiologic review

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Metabolic syndrome, hormones, and maintenance of T cells during aging

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Quantitative analytical method development for the assessment of bioactive quinic acid-type esters and free quinic acid in dietary supplements

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Reduced level of serum thiols in patients with a diagnosis of active disease

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Serum thiols as a surrogate estimate of DNA repair correlates to mammalian life span

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Surrogate indication of DNA repair in serum after long term chiropractic intervention—A retrospective study

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The role of DNA damage repair in aging of adult stem cells

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Further Information

Cat's claw

Blumenthal, M.
The ABC Clinical Guide to Herbs 2003: 23-38

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Efficacy and safety of AC-11

Optigenex, Inc.
2006

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Historical development of Uncaria preparations and their related bioactive components

Editor: Thomas, A.
DNA Damage Repair, Repair Mechanisms and Aging, 2010; 10: 223-236

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The immunomodulatory properties of C-Med 100 and extract of the plant Uncaria tomentosa

Åkesson, C.
Doctoral dissertation, Lund University, 2004

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Reports

Activar Day Cream: Repeated insult patch test

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Activar Eye Cream: Repeated insult patch test

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Activar Eye Cream: The hen's egg test—utilizing the chorioallantoic membrane (HET-CAM)

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Activar Night Cream: Repeated insult patch test

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Salmonella typhimurium reverse mutation assay: Ames test

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Reports

The repair of CPDs in cell culture over 24 hours using antibodies against CPD

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AC-11 research summaries

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Further rationale for using AC-11 to decrease sun induced skin damage (a BIO-EC studies summary)

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Human skin cell explants exposed to UV radiation: The benefits of using AC-11 in an oral model



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U.S. Patents:

Patent No. 6,039,949 "Method of preparation and composition of a water soluble extract of the plant species Uncaria"

This patent is directed to a method for preparing an Uncaria extract and for its administration generally for pharmaceutical purposes.

Patent No. 6,238,675 B1 "Method of preparation and composition of a water soluble extract of the plant species Uncaria for enhancing immune, anti-inflammatory and anti-tumor processes of warm blooded animals"

This patent is directed to the composition of the Uncaria extract described in the ‘949 patent and its pharmaceutical use for enhancement of immune, anti-inflammatory and anti-tumor responses.

Patent No. 6,361,805 B2 "Method of preparation and composition of a water soluble extract of the plant species Uncaria for enhancing immune, anti-inflammatory and anti-tumor and DNA repair processes of warm blooded animals"

This patent covers the pharmaceutical use of an Uncaria extract for DNA repair.

Patent No. 6,964,784 B2 "Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory and anti-tumor and DNA repair processes of warm blooded animals"

This patent covers the pharmaceutical use of an Uncaria extract for DNA repair.

Patent No. 7,579,023 B2 "Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals"

The application is a division of the application which led to the issuance of U.S. Patent No. 6,964,784. Eight claims have been allowed directed to the method for isolating a bioactive component of the Uncaria extract. The claims are further directed to the isolated bioactive component being a carboxy alkyl ester, a quinic action analog, a quinic acid lactone and/or in a pharmaceutical composition.

Patent No. 7,595,064 B2 "Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals"

The application is a continuation-in-part of the application which issued as U.S. Patent No. 6,964,784. There are two allowed claims which are directed to a method of preparing and administering quinic acid or quinic acid salt to enhance DNA repair.

Patent No. 7,955,626 B2 "Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing anti-tumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxy alkyl ester"

The patent is a continuation of the application which issued as U.S. Patent No. 7,579,023. There are 20 claims covering the administration and pharmaceutical use of an isolated purified quinic acid alkyl ester or carboxy alkyl ester for DNA repair or treating disorders associated with the DNA repair process.

Patent No. 7,947,312 "Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals".

The patent is a continuation of the application that issued as U.S. Patent No. 7,595,064. There are ten claims directed to a method of enhancing DNA repair or treating disorders associated therewith by administering quinic acid or quinic acid salt where the quinic acid or salt thereof may form an ammonium salt or chelate thereof.